Hepatitis B refractory to solve the “mystery”

• Author: admin
• Filed under: Hepatitis
• Date: Oct 30,2008

Hepatitis B virus gene and liver cell gene integration of the hepatitis B virus genes and liver cell genes together, and even with the hepatitis B virus in human cells merged into human cells.
Hepatitis B liver-tropic virus
Hepatitis B virus infection in the human body, with the blood flow into the liver through the liver cell membrane of hepatitis B virus directly related to the liver cell membrane receptor, first off shell, the core into the cytoplasm; core-shell off and then, the virus Upbraid gene into the nucleus deduction copy (that is the equivalent of breeding). Drug treatment must be a small molecule to enter cells, liver cells, but also on the role of non-toxic.

Hepatitis B virus pan-tropic
With the advances in technology testing and found that cells infected with hepatitis B virus can not be achieved, such as peripheral blood mononuclear cells, spleen; bone marrow, lymph nodes, small intestine, pancreas, adrenal gland, testis, ovary, and so on. Most people would think convex viral liver cirrhosis or liver cancer surgery, for a hepatitis B infection in the normal number of liver-wide. In fact, in recent years after liver displacement results suggest that in the absence of any preventive measures to prevent hepatitis B under the premise of hepatitis B-related liver disease after liver transplantation, hepatitis B virus re-infection rate high-speed 90%. Hepatitis B immunoglobulin to take expensive and Lamivudine combined anti-virus measures, so that it can no longer reduce the infection rate to 30%. Can be seen in patients with other organizations latent virus, after the liver is no longer the source of infection.

Variability of the hepatitis B virus
Hepatitis B virus is a variant of the virus easily, in order to avoid destruction and the elimination of its body and the occurrence of variation in different parts of the structure of hepatitis B virus occurred, the variation can be spontaneous or after treatment. Variability of the hepatitis B virus pathogenic to humans only change will also affect the hepatitis B diagnosis, treatment and prevention. The hepatitis B virus mutates to the first effective drug to have a special resistance to fight; thereby reducing the effectiveness of treatment or resistance phenomenon.

Hepatitis B virus gene and liver cell gene integration of the hepatitis B virus genes and liver cell genes together, and even with the hepatitis B virus in human cells merged into human cells. A complete human body’s immune system, invasive alien identification of pathogenic micro-organisms through a variety of mechanisms to exclude and eliminate. Hepatitis B virus and the integration of human cells, the body’s immune system to make it difficult to identify, for the loss of hepatitis B virus and the surveillance role of the killing.

Hepatitis B virus can not kill and
Hepatitis B virus into the human liver cells, the role of the enzyme in cells, the formation of the final gene covalently closed circular (CCC DNA), it is a form of hepatitis B virus in the original template, the survival and stability in the cell nucleus, the continuous replication Hepatitis B virus. Today’s killing have not yet developed a template that may be used. At present, the use of drugs is the main template inhibitory copy, stop once the lifting of the inhibitory effect of this template will be re-hepatitis B virus replication.

Mother to child transmission, neonatal infection caused by the intractable
Hepatitis B virus carrying mothers, through intrauterine infection, childbirth and post-delivery period of infection, the mother of hepatitis B virus to newborns, called on the medical vertical transmission. China’s population of more than half of hepatitis B virus carriers is infected. New-born children, immune function is not complete, in particular, specific immune responses rather than the whole weak and can not effectively identify the virus, the performance of immune tolerance to hepatitis B virus, hepatitis B virus infection in the body that no specific immune response to eliminate the virus, Eventually become carriers of hepatitis B virus. The current high price of hepatitis B immunoglobulin and hepatitis B vaccine to prevent the joint, make about 90% of children against hepatitis B virus to carry them.

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