- Author: admin
- Filed under: Virus
- Date: Dec 7,2008
1. Neuromuscular dysfunction acute metabolic alkalosis neuromuscular patients often stress and increased tetany. Is a plasma [Ca + +] decrease, the mechanism of plasma pH value is increased when combined with plasma calcium and more calcium Reduced when metabolic alkalosis led to the obvious hypokalemia, the patient may occur muscle weakness or paralysis, abdominal distension and even intestinal paralysis.
2. Central nervous system dysfunction in patients with irritable have disturbed mental disorder and symptoms such as delirium. At present, the mechanisms that may be related to the central nervous system in γ-aminobutyric acid reduced. γ-aminobutyric acid is a central nervous system material and a disincentive to take part in the maintenance of the central excited inhibition balance. When [H +] decline, glutamic acid decarboxylase activity, γ-aminobutyric acid generation will be reduced; at the same time γ-aminobutyric acid transaminase activity increased, so that the γ-aminobutyric acid decomposition increase. This will rise to inhibit the performance and the weakening of the central nervous system symptoms of excitement.
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Severe metabolic alkalosis of shortage of oxygen is also organized to participate in the role of the central nervous system dysfunction occurred as a result of higher pH value when ammonia from the left curve, oxyhemoglobin dissociation in the organization to reduce the release of oxygen, so patients have oxygen Performance of the symptoms can be excited until he lost consciousness.
3. Hypokalemia often associated with metabolic alkalosis hypokalemia, the ion transfer mechanism. Alkalosis when H + cells move outside the cell in order to balance the reduction of extracellular H +, while K + cells move in order to maintain a neutral power, the process also took place in tubular epithelial cells, cells increase in K +, Pai renal K + will increase, it can lead to hypokalemia. From the front of all the circumstances described, hypokalemia metabolic alkalosis is one of the reasons, and can lead to metabolic alkalosis hypokalemia, the two can reinforce each other, which is to be noted.
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